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Previous studies have linked depression with higher level of inflammatory markers compared to people who are not depressed. When people are given proinflammatory cytokines, people experience more symptoms of depression and anxiety. Chronically higher levels of inflammation due to medical illnesses are also associated with higher rates of depression. Even brain imaging ofpeople with depression show that their brain scans have increased neuroinflammation . When your body is in an inflammatory state fighting off the common cold or flu, you canexperiencesymptoms overlapping withdepression disrupted sleep , depressed mood, fatigue, foggy-headedness, and impaired concentration . A new study published in The Journal of Clinical Psychiatry supports the premise that increased inflammation may play a role in depression. The large study examined data from 14,275 people who were interviewedbetween 2007 and 2012usingthe Patient Health Questionnaire (PHQ-9) to screen for depression and had blood samplesdrawn. They found that people who had depression had 46% higher levels of C-reactive protein (CRP), a marker of inflammatory disease, in their blood samples. The study was only able to establish an association between depression and inflammation but not causation, though it confirmsthe association of depression with high levels of inflammation as measured through CRP. The theory that depression may be viewed as a psychoneuroimmunological disorder can also help explain why efforts to reduce chronic inflammation in the body also improvesand helps prevent depression. Here are five scientifically proven ways you can help reduce inflammation: Reduce your overall stress levels.

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But no one has stepped up yet, raising the bleak possibility that the world's greatest aviation mystery may never be solved. For the families of the aircraft's 227 passengers and 12 crew members, that's a particularly bitter prospect given the recent acknowledgment by officials that they had been looking for the plane in the wrong place all along. In December, the transport bureau announced that a review of the data used to estimate where the plane crashed, coupled with new information on ocean currents, strongly suggested that the plane hit the water in an area directly north of the search zone. But Australia's government rejected a recommendation from the bureau that crews be allowed to search the new area to the north, saying the results of the experts' analysis weren't precise enough to justify continuing the hunt. The three countries' transport ministers reiterated that view in their statement Tuesday, noting: "Whilst combined scientific studies have continued to refine areas of probability, to date no new information has been discovered to determine the specific location of the aircraft." The lack of resolution has caused agony for family members of the flight's passengers, who have begged officials to continue the hunt for their loved ones. "The whole series of events since the plane disappeared has been nothing but frustrating," said Grace Nathan, a Malaysian whose mother was on board Flight 370. "It continues to be frustrating and we just hope they will continue to search. ... They've already searched 120,000 square kilometers. What is another 25,000?" Investigators have been stymied again and again in their efforts to find the aircraft. Hopes were repeatedly raised and smashed by false leads: Underwater signals wrongly thought to be emanating from the plane's black boxes.

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